鐢熺墿閱�(y墨)钘ョ嵉闋啽娼細灏氳尝閬�(d谩)娣卞害瑙ｆ瀽寮垫睙钘ヨ胺鐨勫壍(chu脿ng)鏂颁汉鎵嶆埌(zh脿n)
鐧�(f膩)甯冩檪闁擄細2025-11-14
閬庡幓鍗佸勾锛屼笂娴峰嫉姹熺敓鐗╅啱(y墨)钘ュ熀鍦板緸“涓湅钘ヨ胺”鍔犻�熼倎鍚�“涓栫晫钘ヨ胺”銆�2024—2025 骞达紝闅ㄨ憲鍏ㄧ悆鍓�(chu脿ng)鏂拌棩鍍瑰�奸張鍚戜腑鍦嬪姞閫熻綁(zhu菐n)绉�銆佽硣鏈噸杩旂敘(ch菐n)妤�(y猫)鍩烘湰闈�銆�AI 璩﹁兘钘ョ墿鐮旂櫦(f膩)鎻愰�燂紝鐢熺墿閱�(y墨)钘ユ鍦ㄦ垚鐐轰笂娴锋渶鍏锋埌(zh脿n)鐣ョ鐖姏銆佹渶鍚稿紩楂樼浜烘墠鐨勭敘(ch菐n)妤�(y猫)涔嬩竴銆�
灏嶄簬鐛甸牠鑰岃█锛岄�欓噷涓嶅儏鏄�“姗�(j墨)鏈冨瘑搴︽渶楂樼殑鐢�(ch菐n)妤�(y猫)”锛屾洿鏄�鎸佺簩(x霉)浜斿勾浠ヤ笂淇濇寔楂樿柂銆侀珮澧為暦銆侀珮娴佸嫊鐨�“榛冮噾璩介亾”銆�
鏈瘒鐢�灏氳尝閬�(d谩)鐛甸牠鍩轰簬涓�绶氶爡鐩�銆佷紒妤�(y猫)瑾�(di脿o)鐮旇垏鍊欓伕浜烘暩(sh霉)鎿�(j霉)锛屽叏闈㈣В璁�寮垫睙钘ヨ胺鐨勪汉鎵嶉渶姹傞倧杓�銆侀棞(gu膩n)閸靛礂浣嶈畩鍖栬垏钖叕瓒ㄥ嫝銆�
涓�銆佷笂娴风偤浣曟垚鐐虹敓鐗╅啱(y墨)钘ヤ汉鎵嶇殑“瓒呯礆纾佸牬”锛�
1. 鍏ㄧ悆绱氱敘(ch菐n)妤�(y猫)闆嗚仛鏁堟噳(y墨ng)姝ｅ湪鎴愬舰
寮垫睙宸插尟鑱氾細
· 瓒� 2000 瀹剁敓鐗╅啱(y墨)钘ヤ紒妤�(y猫)
· 20+ 鍏ㄧ悆钘ヤ紒涓湅绺介儴/鐮旂櫦(f膩)涓績
· 30+ 鍦嬪绱氳垏甯傜礆閲嶉粸瀵﹂瀹�
· 瀹屾暣鐨�“鐮旂櫦(f膩)—鑷ㄥ簥—鐢熺敘(ch菐n)—鍟嗘キ(y猫)鍖�”鐢熸厠(t脿i)閺�
閫欑ó鍏ㄩ張姊濈敓鎱�(t脿i)鏄皪浜烘墠鍚稿紩鍔涚殑鏍稿績锛屽洜鐐虹爺鐧�(f膩)宕椼�佽嚚搴婂礂銆佽綁(zhu菐n)鍖栧礂閮借兘鍦ㄥ悓涓�鐗囧湌鍗�(q奴)鎵惧埌璞愬瘜姗�(j墨)鏈�銆�
2. 鍘熷壍(chu脿ng)钘ョ爺鐧�(f膩)閫�(j矛n)鍏�“鐢�(ch菐n)鍝佺垎鐧�(f膩)鏈�”
寰為澏榛炲壍(chu脿ng)鏂般�佺祼(ji茅)妲�(g貌u)鐢熺墿瀛�(xu茅)銆�AI 瑷堢畻鍒�CMC鐢熺敘(ch菐n)锛屼腑鍦嬪壍(chu脿ng)鏂拌棩瀹屾垚浜嗗緸“浠垮埗—Me too—宸暟鍖�”鐨勫崌绱�锛屼汉鎵嶉渶姹傜祼(ji茅)妲�(g貌u)鍥犳鐧�(f膩)鐢熷法澶ц畩鍖栵細
· 绱斿熀绀�(ch菙)鐮旂┒鍚�“鑷ㄥ簥鍙綁(zhu菐n)鍖�”鍌炬枩
· 鏃╃爺宕椾綅锛�DM銆�PD銆佸悎鎴�銆佺敓鐗╁垎鏋愶級鎸佺簩(x霉)绶婄己
· 鏂伴澏榛�銆佸皬鏍搁吀銆佸鎶椼��CGT閮藉湪鎿�(ku貌)鍦�(tu谩n)闅�
闇�姹備笉鍍呭ぇ锛岃�屼笖鏄�鎸佺簩(x霉)鎬х己鍙�銆�
3. 璩囨湰鍥炴鐞嗘��锛屼絾鍎�(y艒u)璩�(zh矛)浜烘墠鍙嶈�屾洿鍊奸將
閬庡幓鍏╁勾锛岃硣鏈洿鎰挎剰鎶曪細
· 鏈夌绶�
· 鏈夋暩(sh霉)鎿�(j霉)
· 鍙晢妤�(y猫)鍖�
閫欑洿鎺ュ付渚嗕竴绋従(xi脿n)璞★細
瓒婃槸鑳芥妸鐢�(ch菐n)鍝佹帹鍒伴棞(gu膩n)閸甸噷绋嬬锛�IND → Phase I → Phase III锛夌殑灏堟キ(y猫)浜烘墠锛岃秺渚涗笉鎳�(y墨ng)姹傘��
浜�銆佸嫉姹熻棩璋锋渶绶婄己鐨勪簲澶ф牳蹇冩澘濉婁汉鎵�
灏氳尝閬�(d谩)绲�(ji茅)鍚堝闅涢爡鐩�锛岀附绲�(ji茅)鍑虹暥(d膩ng)鍓嶆渶绋�缂虹殑宕椾綅闆嗕腑鍦ㄤ簲鍊嬮棞(gu膩n)閸电挵(hu谩n)绡�(ji茅)锛�
1. 鍘熷壍(chu脿ng)钘ョ墿鐮旂櫦(f膩)锛�Discovery锛�
绶婄己鑱蜂綅锛�
· 闈堕粸鐮旂┒绉戝(xu茅)瀹讹紙Target Biology锛�
· 钘ョ墿鍖栧(xu茅)锛�MedChem锛�
· 绲�(ji茅)妲�(g貌u)鐢熺墿瀛�(xu茅)锛堣泲鐧芥櫠楂斻��Cryo-EM锛�
· 鐢熺墿淇℃伅 / AI 钘ョ墿鐮旂櫦(f膩)
· 钘ヤ唬鍕曞姏瀛�(xu茅)锛�DMPK锛�
钖叕瓒ㄥ嫝锛堜互 5–10 骞寸稉(j墨ng)椹楃偤渚嬶級锛�
· MedChem锛氬勾钖� 45–80 钀�
· DMPK锛�50–90 钀�
· AI 钘ョ墿鐮旂櫦(f膩)锛�60–120 钀�锛堟疾骞呮渶鏄庨’锛�
鐥涢粸锛�
澶ч噺浼佹キ(y猫)閮藉湪鎼跺悓涓�鎵规搧鏈�“寰� 0 鍒� 1”闋呯洰缍�(j墨ng)椹楃殑浜烘墠銆�
2. 鑷ㄥ簥闁嬬櫦(f膩)锛�Clinical Development锛�
閫欐槸鐛甸牠闋呯洰閲忔渶澶с�佹垚浜ら�熷害鏈�蹇殑璩介亾銆�
绶婄己鑱蜂綅锛�
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· 娉ㄥ唺浜嬪嫏(w霉)锛�RA锛�
· 鏁�(sh霉)鎿�(j霉)绠＄悊锛�DM锛�
· 鐢熺墿绲�(t菕ng)瑷堝垎鏋愶紙Biostat锛�
钖叕瓒ㄥ嫝锛�
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· 鑷ㄥ簥 PM锛�50–90 钀�
· MSL/閱�(y墨)瀛�(xu茅)缍�(j墨ng)鐞嗭細60–120 钀�
闇�姹傜壒榛烇細
· 绠＄窔瓒婂锛岃嚚搴婂湗(tu谩n)闅婅秺澶�
· 鑷ㄥ簥浜烘墠璺虫Ы闋荤巼楂橈紙1.5–2 骞达級
3. 绱�(x矛)鑳炶垏鍩哄洜娌荤檪锛�CGT锛�
閫欐槸涓婃捣澧為暦鏈�蹇殑鏉垮涔嬩竴锛屽嫉姹熷凡鑱氶泦澶ч噺 CGT 浼佹キ(y猫)锛�CAR-T銆�AAV銆�mRNA銆佸皬鏍搁吀锛�銆�
绶婄己鑱蜂綅锛�
· 宸ヨ棟闁嬬櫦(f膩)锛�PD锛�
· 璩�(zh矛)閲忛珨绯伙紙QA/QC锛�
· 涓婁笅娓哥磾鍖�銆佽唱(zh矛)绮掑埗鍌�
· 鐥呮瘨宸ヨ棟銆佺窗(x矛)鑳炲煿椁�(y菐ng)
· CMC 绠＄窔璨�(f霉)璨�(z茅)浜�
钖叕瓒ㄥ嫝锛�
· PD 宸ョ▼甯細40–70 钀�
· QA/QC锛�35–60 钀�
· CMC 璨�(f霉)璨�(z茅)浜猴細100–200+ 钀�
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4. CDMO锛堝鎵樼爺鐧�(f膩)/鐢熺敘(ch菐n)锛夋摯(ku貌)鐢�(ch菐n)甯朵締鐨勭敤浜烘疆
涓婃捣鍛ㄩ倞锛堟郸鏉�銆侀噾灞便�佹澀宸炲懆閭婏級澶ч噺 CDMO 宸ュ粻鎿�(ku貌)鐢�(ch菐n)銆�
绶婄己鑱蜂綅锛�
· 鐧�(f膩)閰�/绱斿寲宸ョ▼甯�
· 璩�(zh矛)閲忛珨绯昏矤(f霉)璨�(z茅)浜�
· GMP 鐢熺敘(ch菐n)绠＄悊
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钖叕瓒ㄥ嫝锛�6–12 骞寸稉(j墨ng)椹楋級锛�
· 宸ヨ棟涓荤锛�45–80 钀�
· QA/QC 涓荤锛�40–70 钀�
CDMO 浜烘墠娴佸嫊鐗瑰垾蹇�锛屽洜姝ょ嵉闋爡鐩銆佸懆鏈熺煭銆�
5. 鍟嗘キ(y猫)鍖栧礂浣嶏紙Marketing & BD锛夊叏闈笂琛�
闅ㄨ憲瓒婁締瓒婂鐢�(ch菐n)鍝佹鍏� III 鏈�锛屽晢妤�(y猫)鍖栧湗(tu谩n)闅婃摯(ku貌)寮垫槑椤��
绶婄己鑱蜂綅锛�
· 甯傚牬婧�(zh菙n)鍏ワ紙MA锛�
· BD/闋呯洰鍚堜綔
· 鐢�(ch菐n)鍝佸競鍫达紙PMM锛�
· 閱�(y墨)钘ヤ唬琛紙楂樼鐢�(ch菐n)鍝佺窔锛�
钖叕瓒ㄥ嫝锛�
· 甯傚牬婧�(zh菙n)鍏ョ稉(j墨ng)鐞嗭細60–120 钀�
· BD锛�80–150 钀� + 婵�鍕�
涓�銆佷笂娴风敓鐗╅啱(y墨)钘ヤ紒妤�(y猫)鍦�“鎼朵粈涔堟ǎ鐨勪汉”锛熶笁椤炰汉鎵嶆渶鍚冮
1. 鑳芥妸绠＄窔鎺ㄩ��(j矛n)闂�(gu膩n)閸甸噷绋嬬鐨勪汉
渚嬪锛�
· IND 鐢冲牨缍�(j墨ng)椹�
· Phase I/II 瀵︽搷缍�(j墨ng)椹�
· 鏈�“闆欏牨”鎴栨捣澶栨敞鍐婄稉(j墨ng)姝�
閫欎簺浜烘墠涓嶇湅瀛�(xu茅)姝�锛屽彧鐪�“骞叉垚閬庝粈涔�”銆�
2. 鏃㈡噦绉戠爺锛屽張鎳傝綁(zhu菐n)鍖栫殑浜烘墠
姣斿锛�
· 绲�(ji茅)妲�(g貌u)鐢熺墿瀛�(xu茅) + AI
· MedChem + 鑷ㄥ簥鍓嶇爺绌�
· 鐢熺墿绲�(t菕ng)瑷� + 鐪熷涓栫晫鐮旂┒
寰�(f霉)鍚堝瀷浜烘墠 = 绋�缂� + 楂樿柂銆�
3. 鍦嬮殯瑕栭噹 & 鑻辫獮鑳藉皪鎺ユ捣澶�
鐗瑰垾鏄� BD銆侀啱(y墨)瀛�(xu茅)銆佹敞鍐婏紝璺ㄥ湅婧濋�氳兘鍔涚洿鎺ュ奖闊胯柂璩囩瓑绱�銆�
鍥�銆佺嵉闋瑙掞細鐐轰粈涔堣鐢熺墿閱�(y墨)钘ユ槸鏈締浜斿勾鏈�濂界殑璩介亾锛�
1. 浜烘墠缂哄彛澶�锛岄爡鐩垚浜ゅ揩
浠讳綍“缂哄彛宸ㄥぇ”鐨勮妤�(y猫)锛岀嵉闋爡鐩氨鏈冨锛屽懆鏈熷氨鏈冪煭銆佺敓鎰忓氨鏈冪┅(w臎n)瀹氥��
2. 涓珮绔礂浣嶅崰姣旈珮锛屽児鍊奸噺澶�
鐢熺墿閱�(y墨)钘ュ礂浣嶆櫘閬嶈柂璩囬珮銆佸皥妤�(y猫)搴﹀挤锛屾槸澶╃劧鐨勭嵉闋�“榛冮噾宕椾綅”銆�
3. 浼佹キ(y猫)灏嶅皥妤�(y猫)鐛甸牠渚濊炒搴﹂珮
鍥犵偤锛�
· HR 寰堥洠瑭曚及绉戝(xu茅)瀹跺皥妤�(y猫)鑳藉姏
· 闇�瑕佺嵉闋簩娆＄閬告暩(sh霉)鎿�(j霉)璩�(zh矛)閲�
· 闇�瑕佸崝(xi茅)鍔╂簼閫� Offer銆佸湗(tu谩n)闅婂尮閰�銆佷汉閬哥┅(w臎n)瀹氭��
鍠潬鎷涜仒缍�(w菐ng)绔欐牴鏈笉澶�銆�
浜斻�佸皻璩㈤仈(d谩)瑙�瀵燂細2025 骞寸敓鐗╅啱(y墨)钘ヤ汉鎵嶈定鍕㈤爯(y霉)娓�
鎴戝�戝垽鏂凤細
1. AI × R&D 鐨勫礂浣嶇辜绾�(x霉)鏆存疾
AI 瑷堢畻鍖栧(xu茅)銆�AI 铔嬬櫧瑷�(sh猫)瑷�銆�AI 绲�(ji茅)妲�(g貌u)闋�(y霉)娓皣鎴愮偤“浜旀槦绱氱穵缂�”銆�
2. CMC 鍜屾敞鍐婁汉鎵嶆湭渚嗗叐骞翠粛鏄己鍙ｆ渶澶х兢楂�
闅ㄨ憲鏇村绠＄窔閫�(j矛n)鍏ヤ腑鍚庢湡锛�CMC銆�RA 鐨勮柂閰垏闇�姹傞兘鏈冪辜绾�(x霉)璧伴珮銆�
3. 娴峰鐮旂櫦(f膩)鍥炴祦浜烘墠灏囨湁鏂颁竴娉㈡(j墨)鏈�
“娴锋浜烘墠 + 鏈湡鐮旂櫦(f膩)楂旂郴”鎴愮偤浼佹キ(y猫)鏈�鐪嬮噸绲勫悎銆�
4. 鍟嗘キ(y猫)鍖栨摯(ku貌)寮靛皣閫�(j矛n)鍏ラ珮宄版湡
PD-1銆�ADC銆佺窗(x矛)鑳炴不鐧傜瓑鍟嗘キ(y猫)鍖栫鐖縺鐑堬紝閵峰敭鑸囧競鍫存簴(zh菙n)鍏ユ渻鎸佺簩(x霉)鎿�(ku貌)鎷�銆�
寮垫睙钘ヨ胺锛屼粛鏄腑鍦嬬嵉闋殑“绗竴楂樺湴”
鐢熺墿閱�(y墨)钘ユ槸涓�鍫村皥妤�(y猫)澹佸妤甸珮鐨勭敘(ch菐n)妤�(y猫)绔惰辰锛屼汉鎵嶆案閬�(yu菐n)鏄焙瀹氫紒妤�(y猫)鎴愭晽鐨勬牳蹇冭畩閲�銆傚嫉姹熻棩璋风殑宕涜捣锛屼笉鍍呮剰鍛宠憲涓湅鍓�(chu脿ng)鏂拌棩姝ｅ湪娌栨搳鍏ㄧ悆鑸炶嚭锛屼篃鎰忓懗钁�鐢�(ch菐n)妤�(y猫)鍗囩礆姝ｅ湪瀛曡偛鍓嶆墍鏈湁鐨勯珮绔汉鎵嶇磪鍒�銆�
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